chlorthalidone trade name

Thalitone has a different formulation and is more potent. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Stones in the urinary system can form in the kidneys and can sometimes travel down towards the bladder to give rise to acute colics. OH I o+ s NH2 CHLORTHALIDONE 3 1.2 Trade Names Hygroto@ x Regrotoa Hydro-Long Hydroton Igroton Chlorthalidone is also a component of Regrotor@ and Demi-Regroton combination products containing Chlorthalidone in combination with reserpine. Drug Name : Chlorthalidone. ", "Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia", "Thiazide-Associated Hypercalcemia: Incidence and Association With Primary Hyperparathyroidism Over Two Decades", "Obesity, hypertension and diuretic use as risk factors for incident gout: a systematic review and meta-analysis of cohort studies", "The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs", "Chlorthalidone: don't call it "thiazide-like" anymore", "Mechanisms and pharmacogenetic signals underlying thiazide diuretics blood pressure response", "The abuse of diuretics as performance-enhancing drugs and masking agents in sport doping: pharmacology, toxicology and analysis", "Yasir Shah provisionally suspended after failed drugs test", https://en.wikipedia.org/w/index.php?title=Chlortalidone&oldid=992686053, World Anti-Doping Agency prohibited substances, Drugboxes which contain changes to watched fields, Wikipedia medicine articles ready to translate, Srpskohrvatski / српскохрватски, Creative Commons Attribution-ShareAlike License, This page was last edited on 6 December 2020, at 15:54. [26] In people who have had multiple episodes of calcium oxalate kidney stones, chlortalidone lowers the risk of having another episode of kidney stones. Renal impairment: Chlorthalidone dosage should be reduced in moderate renal failure - every 24 or 48 h - and should not be used in advanced renal failure. Regardless of cause, chlortalidone may sometimes improve the severity of edema by reducing intravascular volume and thereby reducing intravascular hydrostatic pressure. More Info about Chlorthalidone. Chlortalidone is banned for some sports (including cricket) because it is a diuretic, and can be used to reduce body weight or to mask the concomitant use of performance-enhancing drugs. [50] Sports such as wrestling or boxing categorize athletes according to body weight; taking a diuretic such as chlortalidone may lower body weight, and thereby permit an athlete to compete in a lighter weight class, which would provide an advantage. Chlorthalidone belongs to a group of drugs called diuretics ("water pills") which help the body get rid of excess fluid by increasing the amount of salt and water the kidneys remove from the blood. When the treatments were compared chlorthalidone was significantly better than the placebo or magnesium hydroxide (p less than 0.01) [3]. [10][11], Chlortalidone is considered a first-line medication for treatment high blood pressure. Azilsartan is an angiotensin II receptor antagonist used in the treatment of hypertension, developed by Takeda. [1] It is also used to prevent calcium-based kidney stones. This reduced delivery of solute to the collecting tubule and medullary collecting duct allows increased water resorption and higher concentration of urine, which leads to reversal of nephrogenic diabetes insipidus by a means that is independent of vasopressin. Diuretics such as chlortalidone also reduce the urine concentration of concomitantly-taken performance-enhancing drugs or of their metabolites, thus making it more difficult to detect these drugs using urine testing. They are available as follows: NDC 16714-128-01 in bottle of 100 tablets a sulfonamide diuretic, C14H11ClN2O4S, used in the management of hypertension. Disclaimer - All information and content on this site are for information and educational purposes only. In high blood pressure it is a preferred initial treatment. Description and Brand Names. Chlortalidone, also known as chlorthalidone, is a diuretic medication used to treat high blood pressure, swelling including that due to heart failure, liver failure, and nephrotic syndrome, diabetes insipidus, and renal tubular acidosis. Clonidine and chlorthalidone combinations are used in the treatment of high blood pressure (hypertension). This site complies with the HONcode standard for trustworthy health information: verify here. Chlorthalidone(Thalitone) generic is a diuretic, prescribed for high blood pressure and fluid retention. This prolonged action of chlortalidone despite missing doses may account for the higher efficacy of chlortalidone compared to the shorter half-life medication, hydrochlorothiazide. [29], Chlortalidone (or other thiazide medication) is a key component of treatment of nephrogenic diabetes insipidus. Chlorthalidone Tablets, USP are available containing 25 mg or 50 mg of Chlorthalidone, USP. [47], Chlortalidone is in the sulfamoylbenzamide class. Definition of chlorthalidone in the Definitions.net dictionary. [13][14][5][6], Trials of chlortalidone for high blood pressure found that lower doses of chlortalidone (e.g., 12.5 mg daily in ALLHAT study) had maximal blood pressure lowering effect and that higher doses did not lower it more. 2. ... a diuretic (trade names Hygroton and Thalidone) used to control hypertension and conditions that cause edema; effective in lowering blood pressure to prevent heart attacks. [1] It is taken by mouth. Liver disease: There is a risk of precipitating hepatic encephalopathy in patients with liver cirrhosis and ascites. There is evidence that chlortalidone is superior to hydrochlorothiazide for reducing the mass of the left ventricle of the heart in persons with enlargement of the left ventricle of the heart. [1][2] In high blood pressure it is a preferred initial treatment. [24] A secondary analysis of data from the ALLHAT study found that chlortalidone reduced risk of hip and pelvis fracture. chlorthalidone systemic. Diabetes and hypertension (high blood pressure) are significant health problems worldwide, but like cardiac disease and fatty liver disease, people of Indian origin are disproportionately affected. [1], Common side effects include low blood potassium, low blood sodium, high blood sugar, dizziness, and erectile dysfunction. Chlorthalidone is a long acting thiazide-like diuretic of the sulfamoylbenzamide class that is devoid of the benzothiadiazine structure. [1][2][4] Some reviews have found chlortalidone to have a higher risk of side effects than hydrochlorothiazide,[5][6] while other reviews have found a similar risk. [16], Chlortalidone and other thiazide diuretics are effective for lowering high blood pressure in persons with chronic kidney disease, although the risk of adverse effects is higher in these persons. Eventually, cardiac output returns to normal, and plasma and extracellular fluid volume return to slightly less than normal, but a reduction in peripheral vascular resistance is maintained, thus resulting in an overall lower blood pressure. It is also sold as a combination drug with chlortalidone under the brand name Edarbyclor. US Brand Name. CHLORTHALIDONE Pronunciation: (klor thal' i done) Trade Name(s): Hythalton, hygroton, bigroton Why it is prescribed: Chlorthalidone, a water pill, is used to treat high blood pressure and fluid retention caused by various conditions.It causes the kidney to eliminate unneeded water and salt into the urine. Thus, in persons with diminished kidney function, the clearance of chlortalidone is reduced and the elimination half-life is increased. The 25 mg tablets are light yellow, round, flat faced beveled edged unscored tablets debossed with "Z25" on one side of the tablet and plain on other side. There is uncertainty about the mechanism of the blood pressure-lowering effect that occurs during chronic exposure to chlortalidone. Generic chlorthalidone, while available, is not equivalent to brand-name Thalitone. Drug information provided by: IBM Micromedex. [44] Initially, diuretics lower blood pressure by decreasing cardiac output and reducing plasma and extracellular fluid volume. 14, pp. Giving chlortalidone while simultaneously restricting dietary sodium intake causes mild hypovolemia (low intravascular volume), which induces isotonic reabsorption of solute from the proximal renal tubule, reducing solute delivery in the renal collecting tubule and renal medullary collecting duct. By blocking sodium ion resorption in the distal convoluted tubule, chlortalidone induces an increase in excretion of sodium ion in urine (natriuresis). [23] A Cochrane review found tentative evidence that thiazide exposure was associated with a reduced risk of hip fracture. Side effects, drug interactions, dosing information, and pregnancy safety should be reviewed prior to … [7][8] While it may be used in pregnancy it is a less preferred option. Chlorthalidone directly inhibits sodium and chloride reabsorption on the luminal membrane of the early segment in the distal convoluted tubule (DCT) in the kidney. Meaning of chlorthalidone. Drug information provided by: IBM Micromedex. Thalitone; Descriptions. It is 2-chloro-5(1-hydroxy- 3-oxo-1- isoindolinyl) benzenesulfonamide with the following structural formula: Chlortalidone is eliminated from the body mostly by the kidney, as unchanged drug. chlorthalidone is a topic covered in the Davis's Drug Guide.. To view the entire topic, please sign in or purchase a subscription.. Anesthesia Central is an all-in-one web and mobile solution for treating patients before, during, and after surgery. Academic Press, 1985. Chlorthalidone, 25 mg daily, was at least as effective for hypertension as 50 and 75 mg wi MedChem Express HY-15833: Membrane Tranporter/Ion Channel MedChem Express HY-15833 100,101 This difference in duration of action by chlorthalidone translated into an additional 7-mm Hg reduction in SBP when substituted for hydrochlorothiazide. Cautions. Due to its long half-life, chlortalidone may accumulate in newborns via breast milk, despite receiving only about 6% of the maternal weight-adjusted dose. High Blood Pressure. As it lacks the benzothiadiazine structure of the thiazide-type diuretics, it is called a thiazide-like diuretic. Chlorthalidone - Trade Names: Amlovas-CH (5mg/12.5mg) Amlovas-CH (5mg/6.25mg) Catapres - DIU (0.1mg/15mg) Catapres DIU: Cortel- CH (40mg/12.5mg) CTD … It has a long half-life and therefore a prolonged diuretic action, which results in continued diuretic effects despite a skipped dose. Nephrogenic diabetes insipidus occurs when the kidney is unable to produce concentrated urine because it has an inadequate response to vasopressin-dependent removal of free water from the renal tubular filtrate. The most common adverse reaction in adults is diarrhea. This can result in a low blood concentration of potassium and chloride as well as a mild metabolic alkalosis; however, the diuretic effect of chlortalidone is not affected by the acid-base balance of the person being treated. Chlortalidone is a diuretic, which means it helps your body get rid of extra salt (sodium) and water.It works by increasing the amount of urine (pee) you make. Anuria. Summary. High blood pressure or hypertension is a chronic condition, which usually lasts a lifetime once it is developed. Chlorthalidone (Thalitone [Hygroton discontinued brand in USA]) is a medication prescribed for the treatment of high blood pressure, congestive heart failure, and edema. Chlorthalidone is a "water pill " (diuretic). Chlorthalidone is used alone or together with other medicines to treat high blood pressure (hypertension). [51], O=S(=O)(N)c1c(Cl)ccc(c1)C2(O)c3ccccc3C(=O)N2, InChI=1S/C14H11ClN2O4S/c15-11-6-5-8(7-12(11)22(16,20)21)14(19)10-4-2-1-3-9(10)13(18)17-14/h1-7,19H,(H,17,18)(H2,16,20,21). Clorpres; Descriptions. [17][18], Chlortalidone is used to treat left ventricular hypertrophy in the heart; it works chiefly by lowering blood pressure, and thereby reducing systemic vascular resistance. Brand names: Diuril, Diuril Sodium. Chlortalidone is slowly absorbed from the gastrointestinal tract after oral ingestion. Chlortalidone reduces reabsorption of sodium and chloride primarily through inhibition of the Na+/Cl− symporter in the apical membrane of distal convoluted tubule cells in the kidney. It is also used to prevent calcium-based kidney stones. Chlorthalidone systemic is used in the treatment of: Edema. Chlorthalidone is a prescription medication used to treat high blood pressure and fluid retention caused by congestive heart failure and other conditions. Effects generally begin within three hours and last for up to three days. Chlorthalidone is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. [5] How it works is not completely clear but is believed to involve increasing the amount of sodium and water lost by the kidneys. Chlorthalidone only comes as a tablet you take by mouth. [45], As with other thiazide diuretics, chlortalidone crosses the placenta and is excreted in breast milk. [30], Some reviews have found a similar risk as hydrochlorothiazide,[7][8] while other reviews found a higher risk of side effects.[5][6]. [1][2][3] Other side effects may include gout, low blood magnesium, high blood calcium, allergic reactions, and low blood pressure. In Analytical Profiles of Drug Substances, vol. High Blood Pressure. It is taken by mouth. [20], Chlortalidone may improve edema (swelling) by increasing urinary salt and water excretion, lowering intravascular hydrostatic pressure and thereby lowering transcapillary pressure (see Starling Equation). [2] In 2017, it was the 173rd most commonly prescribed medication in the United States, with more than three million prescriptions. Edema due to increased hydrostatic pressure may be a result of serious cardiopulmonary disease (which reduces glomerular perfusion in the kidney) or to kidney injury or disease (which may reduce glomerular excretion of salt and water by the kidney) or due to relatively benign conditions such as menstrual-related fluid retention, or as an adverse effect of dihydropyridine calcium channel blockers, which commonly cause swelling of the feet and lower legs. US Brand Name. What is chlorthalidone (Hygroton, Thalitone)? Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. you'll often start with a thiazide diuretic, such as: * chlorthalidone (hygroton) * chlorothiazide (diuril) * hydrochlorothiazide or hctz (esidrix, hydrodiuril, microzide) * indapamide (lozol) * The frequency and severity of these adverse effects is much reduced when chlortalidone is used at lower doses (e.g., 12.5 mg per day). Brand names: Hygroton, Thalitone. [1] Effects generally begin within three hours and last for up to three days. Look at other dictionaries: chlorthalidone — /klawr thal i dohn , klohr /, n. Pharm. [22], Chlortalidone decreases mineral bone loss by promoting calcium retention by the kidney, and by directly stimulating osteoblast differentiation and bone mineral formation. * Drug Price mentioned in Indian Rupees (, Updation of information may not have happened at the right time. By increasing the delivery of sodium to the distal renal tubule, chlortalidone indirectly increases potassium excretion via the sodium-potassium exchange mechanism (i.e. Generic chlorthalidone comes in three different strengths, ranging from 25 to 100 mg, and is manufactured by several different companies. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. It is marketed in tablet form under the brand name Edarbi as the prodrug azilsartan medoxomil. [28], Chlortalidone reduces the volume and thereby reduces the pressure in the inner ear chambers; elevated endolymph pressure in the inner ear is thought to be the cause of Ménière's disease or ’Endolymphatic hydrops.’ Synthesis of evidence from multiple small, low-quality studies indicates that chlortalidone or other thiazide diuretics are effective for Ménière's Disease. chlorothiazide systemic. 1.3 Appearance, Color Chlorthalidone is a white to yellowish-white crystalline powder. Chlortalidone is the official name of the medication according to the (INN/BAN), which is the medication naming system coordinated by the World Health Organization. Drug class (es): thiazide diuretics. Chlorthalidone is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Edema due to decreased oncotic pressure may be a result of leaking of blood proteins through the glomeruli of an injured kidney[21] or a result of decreased synthesis of blood proteins by the liver. It increases the amount of urine you make, especially when you first start the medication. Generic Name: . [CHLOR 2 + (ph)thali(mi)d(ine) a chemical component of the drug + (KET)ONE] * * * … apical ROMK/Na channels coupled with basolateral Na+/K ATPases). Highlights for chlorthalidone. Chlorthalidone is available under the following different brand names: Hygroton, Thalitone, and Chlorthalid. [42] Some of chlortalidone's diuretic effect is also due to this inhibition of carbonic anhydrase in the proximal tubule. [19] Chlortalidone is superior to angiotensin converting enzyme Inhibitors or angiotensin II receptor blockers for inducing regression of enlargement of the left ventricle, which is the main pumping chamber of the heart. Chlortalidone, also known as chlorthalidone, is a diuretic medication used to treat high blood pressure, swelling including that due to heart failure, liver failure, and nephrotic syndrome, diabetes insipidus, and renal tubular acidosis. noun a diuretic (trade names Hygroton and Thalidone) used to control hypertension and conditions that cause edema; effective in lowering blood pressure to prevent heart attacks • Syn: ↑Hygroton, ↑Thalidone • Hypernyms: ↑diuretic drug, ↑diuretic,… It is a monosulfamyl diuretic that differs chemically from thiazide diuretics in that a double-ring system is incorporated in its structure. Chlortalidone's diuretic effect is diminished in persons with kidney impairment. [25], Chlortalidone reduces the amount of calcium excreted in urine, reducing the risk of calcium oxalate kidney stones. [48] Chlortalidone is freely soluble in dimethylacetamide (DMA), dimethylformamide (DMF), dimethylsulfoxide (DMSO), and methanol; it is also soluble in warm ethanol.[49]. Always seek the advice of a qualified physician for medical diagnosis and treatment.Full Disclaimer, Advertise with us | Medindia Copyright | Privacy Policy | Terms of Use © All Rights Reserved 1997 - 2021. National Center for Biotechnology Information. Atenolol/chlorthalidone is a combination of atenolol and chlorthalidone (Hygroton) used for the treatment of high blood pressure.Atenolol is a beta-adrenergic blocking agent that blocks the effects of adrenergic drugs, for example, adrenaline or epinephrine, on nerves of the sympathetic nervous system.Atenolol reduces the heart rate and is useful in treating abnormally rapid heart rhythms. [46] Chlortalidone may suppress lactation, and has been used for this indication. 1-36. Edema may be caused by either increased hydrostatic pressure or reduced oncotic pressure in the blood vessels. Chlorthalidone is an oral antihypertensive/diuretic. Brand Name : Contains: Dosage Form : Manufacturer: Price(Tk.) Use in pregnancy: It is better to avoid Chlorthalidone as it crosses the placenta. Chlorothiazide systemic is used in the treatment of: Edema. THALIDON : Chlorthalidone USP 25mg/tablet: Tablet: Popular Pharmaceuticals Ltd. 30s pack: 60.00 MRP [1], Chlortalidone was patented in 1957 and came into medical use in 1960. Chlorthalidone manufacturer,Chlorthalidone 15mg,clonidine hcl 0.1mg,Chlorthalidone 100mg,Chlorthalidone 12.5mg Largest Generic Manufacturer,Formula,producing With chemical method according to the present invention Suppliers List,Molecular Structure,Weight,IUPAC,Synonyms for Chlorthalidone 100 Chlorthalidone(Thalitone) generic is a diuretic, prescribed for … Chlortalidone is used to treat high blood pressure (hypertension), and is also used to lessen extra fluid in the body (called oedema) caused by conditions such as heart failure, liver disease, or kidney disease. Chlorthalidone is the official name of the medication according to the (USAN), which is the medication naming system coordinated by the USAN Council, which is co-sponsored by the American Medical Association (AMA), the United States Pharmacopeial Convention (USP), and the American Pharmacists Association (APhA). [1] Some recommend chlortalidone over hydrochlorothiazide. Description and Brand Names. Singer, Jeff M., Michael J. O'Hare, Carl R. Rehm, and John E. Zarembo. What is chlortalidone? It also helps to relax the blood vessels so that blood can flow more easily. [43] Chronic exposure to chlortalidone decreases the glomerular filtration rate. 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[9] It is available as a generic medication. Chlorthalidone oral tablet is only available as a generic drug.It doesn’t have a brand-name version. "Chlorthalidone." [41] Although chlortalidone is often referred to as a "thiazide-like" diuretic, it is unlike thiazide diuretics in that, in addition to its inhibition of the Na+/Cl− symporter, it also strongly inhibits multiple isoforms of carbonic anhydrase.

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